Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long‐Term Failure

Abstract excerpt

Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field. After that, more pessimistic views spread when long-term results of the clinical outcome were published. A progressive loss of the beta-cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly...

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