Article
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Westermark P, Engström U, Johnson K H, Westermark G T, Betsholtz C
Abstract excerpt
Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 diabetic humans and diabetic cats. The connection between IAPP amyloid formation and diabetes is unknown, but a...
Topics
- Amino Acid Sequence
- Amyloid
- Amyloidosis
- Animals
- Cats
- Cricetinae
- Diabetes Mellitus, Type 2
- Humans
- Islet Amyloid Polypeptide
- Islets of Langerhans
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Protein Precursors
- Rats
- Sequence Homology, Nucleic Acid
- Species Specificity