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Article

Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes.

Molecular biology of the cell - 15 Nov 2010

Kasbek Christopher, Yang Ching-Hui, Fisk Harold A

Abstract excerpt

Extra centrosomes are found in many tumors, and their appearance is an early event that can generate aberrant mitotic spindles and aneuploidy. Because the failure to appropriately degrade the Mps1 protein kinase correlates with centrosome overproduction in tumor-derived cells, defects in the factors that promote Mps1 degradation may contribute to extra centrosomes in tumors. However, while we have recently...

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Identifiers

PMID: 20861309
DOI: 10.1091/mbc.E10-04-0281
PMCID: PMC2982088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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