Article
Overlapping reading frames in closely related human papillomaviruses result in modular rates of selection within E2.
The Journal of general virology - 1 May 2005
Narechania Apurva, Terai Masanori, Burk Robert D
Abstract excerpt
A core group of four open reading frames (ORFs) is present in all known papillomaviruses (PVs): the E1 and E2 replication/transcription proteins and the L1 and L2 structural proteins. Because they are involved in processes that are essential to PV propagation, the sequences of these proteins are well-conserved. However, sequencing of novel subtypes for human papillomaviruses (HPV) 54 (AE9) and 82 (AE2/IS39),...
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