Article
The genetic fate of molecularly cloned simian immunodeficiency virus in experimentally infected macaques.
Virology - 1 Nov 1991
Johnson P R, Hamm T E, Goldstein S, Kitov S, Hirsch V M
Abstract excerpt
We have examined genetic variation of the simian immunodeficiency virus (SIV) in four macaques inoculated with virions derived from molecular clones of proviral DNA. Our data demonstrated that the SIV genome is capable of rapid and extensive genetic variation. This variation was especially large...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Cloning, Molecular
- Codon
- DNA Nucleotidyltransferases
- DNA, Viral
- Genes, env
- Genetic Variation
- HIV-2
- Integrases
- Macaca mulatta
- Molecular Sequence Data
- Polymerase Chain Reaction
- Proviruses
- Restriction Mapping
- Sequence Homology, Nucleic Acid