Distinct variation pattern in the env of macrophage-tropic simian immunodeficiency virus in vivo demonstrated by denaturing gradient gel electrophoresis.

Abstract excerpt

Genetic variations, occurring during the infection in the AIDS animal model using a molecular clone virus, often consist of single nucleotide substitutions distributed sparsely in the viral genome. A highly sensitive method was developed to detect such mutations, consisting of denaturing gradient gel electrophoresis (DGGE) and direct sequencing. The genetic variation in the env of a macrophage tropic simian...

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