Article
BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype.
Journal of neuroscience research - 1 Jul 2009
Silva Ana, Pereira Jorge, Oliveira Catarina R, Relvas João Bettencourt, Rego A Cristina
Abstract excerpt
Differentiation of neurosphere-derived cells is regulated by extracellular cues, namely, growth factors and proteins of the extracellular matrix (ECM). In this study we analyzed the influence of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), retinoic acid plus potassium chloride (RA-KCl), and the nonsynthetic ECMs laminin (LN) and fibronectin (FN) versus the synthetic adhesion substrate...
Topics
- Animals
- Animals, Newborn
- Biomarkers
- Brain-Derived Neurotrophic Factor
- Cell Differentiation
- Cell Proliferation
- Cell Survival
- Cells, Cultured
- Extracellular Matrix Proteins
- Fibronectins
- Intermediate Filament Proteins
- Laminin
- Mice