Article
Adult height variants affect birth length and growth rate in children.
Human molecular genetics - 15 Oct 2011
Paternoster Lavinia, Howe Laura D, Tilling Kate, Weedon Michael N, Freathy Rachel M, Frayling Timothy M, Kemp John P, Smith George Davey, Timpson Nicholas J, Ring Susan M, Evans David M, Lawlor Debbie A
Abstract excerpt
Previous studies identified 180 single nucleotide polymorphisms (SNPs) associated with adult height, explaining ∼10% of the variance. The age at which these begin to affect growth is unclear. We modelled the effect of these SNPs on birth length and childhood growth. A total of 7768 participants in the Avon Longitudinal Study of Parents and Children had data available. Individual growth trajectories from 0 to 10...
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