Article
Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.
Obesity (Silver Spring, Md.) - 1 Jul 2009
Grant Struan F A, Bradfield Jonathan P, Zhang Haitao, Wang Kai, Kim Cecilia E, Annaiah Kiran, Santa Erin, Glessner Joseph T, Thomas Kelly, Garris Maria, Frackelton Edward C, Otieno F George, Shaner Julie L, Smith Ryan M, Imielinski Marcin, Chiavacci Rosetta M, Li Mingyao, Berkowitz Robert I, Hakonarson Hakon
Abstract excerpt
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations. We investigated the association in the context of the childhood form of the disease utilizing data from our ongoing GWA study in a...
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