Geographical structure and differential natural selection among North European populations.

doi:10.1101/gr.083394.108

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Article

Geographical structure and differential natural selection among North European populations.

Genome research - 1 May 2009

McEvoy Brian P, Montgomery Grant W, McRae Allan F, Ripatti Samuli, Perola Markus, Spector Tim D, Cherkas Lynn, Ahmadi Kourosh R, Boomsma Dorret, Willemsen Gonneke, Hottenga Jouke J, Pedersen Nancy L, Magnusson Patrik K E, Kyvik Kirsten Ohm, Christensen Kaare, Kaprio Jaakko, Heikkilä Kauko, Palotie Aarno, Widen Elisabeth, Muilu Juha, Syvänen Ann-Christine, Liljedahl Ulrika, Hardiman Orla, Cronin Simon, Peltonen Leena, Martin Nicholas G, Visscher Peter M

Abstract excerpt

Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom,...

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PMID: 19265028
DOI: 10.1101/gr.083394.108
PMCID: PMC2675969

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