Article
The fine-scale genetic structure of the British population.
Nature - 19 Mar 2015
Leslie Stephen, Winney Bruce, Hellenthal Garrett, Davison Dan, Boumertit Abdelhamid, Day Tammy, Hutnik Katarzyna, Royrvik Ellen C, Cunliffe Barry, Lawson Daniel J, Falush Daniel, Freeman Colin, Pirinen Matti, Myers Simon, Robinson Mark, Donnelly Peter, Bodmer Walter
Abstract excerpt
Fine-scale genetic variation between human populations is interesting as a signature of historical demographic events and because of its potential for confounding disease studies. We use haplotype-based statistical methods to analyse genome-wide single nucleotide polymorphism (SNP) data from a carefully chosen geographically diverse sample of 2,039 individuals from the United Kingdom. This reveals a rich and...
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