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Selection of H5N1 Influenza Virus PB2 during Replication in Humans

6 Mar 2009

Abstract excerpt

Highly pathogenic H5N1 influenza viruses continue to cause concern, even though currently circulating strains are not efficiently transmitted among humans. For efficient transmission, amino acid changes in viral proteins may be required. Here, we examined the amino acids at positions 627 and 701 of the PB2 protein. A direct analysis of the viral RNAs of H5N1 viruses in patients revealed that these amino acids...

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PMID: 19264775
DOI: 10.1128/jvi.00063-09

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