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Article

PreproNPY Pro7 protects against depression despite exposure to environmental risk factors.

Journal of affective disorders - 1 Nov 2009

Sjöholm Louise K, Melas Philippe A, Forsell Yvonne, Lavebratt Catharina

Abstract excerpt

BACKGROUND: There is extensive evidence, from both clinical cases and rodent models, for reduced levels of the widely expressed neuropeptide Y (NPY) in anxiety and depressive disorders. The rare allele of the Leu7Pro polymorphism in the signal peptide of preproNPY has been associated with higher...

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Identifiers

PMID: 19264362
DOI: 10.1016/j.jad.2009.02.009

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19264362-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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PreproNPY Pro7 protects against depression despite exposure to environmental risk factors.PMID 19264362Read ↗

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Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans.Semantic proximity Read ↗

Interaction of the neuropeptide S receptor gene Asn¹⁰⁷Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour.Semantic proximity Read ↗

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect.Semantic proximity Read ↗

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