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Article

Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2.

Oncogene - 26 Apr 2007

Cho D-H, Lee H-J, Kim H-J, Hong S-H, Pyo J-O, Cho C, Jung Y-K

Abstract excerpt

Apaf-1-interacting protein (APIP) was previously isolated as an inhibitor of mitochondrial cell death interacting with Apaf-1. Here, we report a hypoxia-selective antiapoptotic activity of APIP that induces the activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Stable expression of APIP in C2C12 (C2C12/APIP) cells suppressed cell death induced by hypoxia and etoposide. Unlike etoposide,...

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Share to Antineoplastic Agents, Phytogenic
Share to Apoptotic Protease-Activating Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoresis, Gel, Two-Dimensional

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Share to Mitogen-Activated Protein Kinase 1

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Source

Identifiers

PMID: 17086211
DOI: 10.1038/sj.onc.1210080

Genes

APIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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