Article
Lack of primary mutations associated with integrase inhibitors among HIV-1 subtypes B, C, and F circulating in Brazil.
Journal of acquired immune deficiency syndromes (1999) - 1 May 2009
Passaes Caroline Bittencourt, Guimarães Monick Lindenmeyer, Fernandez Saada Lima Chequer, Lorete Roberta Dos Santos, Teixeira Sylvia Lopes Maia, Fernandez José Carlos Couto, Morgado Mariza Gonçalves
Abstract excerpt
BACKGROUND: Antiretroviral drugs targeting integrase (IN) have recently been approved for use in combined and salvage therapeutic interventions. OBJECTIVE: To evaluate the presence of natural polymorphisms and resistance mutations associated with IN inhibitors among HIV-1 subtypes B, C, and F samples obtained from drug-naive individuals and patients failing highly active antiretroviral therapy in Brazil. METHODS:...
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