Article
The SnoB study: frequency of baseline raltegravir resistance mutations prevalence in different non-B subtypes.
Medical microbiology and immunology - 1 Nov 2011
Sierra Saleta, Lübke Nadine, Walter Hauke, Schülter Eugen, Reuter Stefan, Fätkenheuer Gerd, Bickel Markus, da Silva Hugo, Kaiser Rolf, Esser Stefan
Abstract excerpt
The SnoB study analysed the variability of the integrase (IN) gene of non-B viruses from treatment-naïve patients to determine whether non-B subtypes carry natural resistance mutations to raltegravir (RAL). Plasma viral RNA from 427 patients was gained, and IN sequences were subtyped and screened for subtype-specific highly-variable residues. Seven viruses of different subtypes were phenotypically tested for RAL...
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