Article
HIV-1 genetic diversity and transmitted drug resistance to integrase strand transfer inhibitors among recently diagnosed adults in Porto Alegre, South Brazil.
The Journal of antimicrobial chemotherapy - 28 Nov 2022
Nunes Cynara Carvalho, Sita Alexandre, Mallmann Larissa, Birlem Gabriela Espindola, de Mattos Larissa Gomes, Da Silva Daila Haemk, Furlanetto Karen Oliveira, Hansen Alana Witt, De Almeida Paula Rodrigues, Fleck Juliane Deise, Spilki Fernando Rosado, de Matos Almeida Sabrina Esteves, Weber Matheus Nunes
Abstract excerpt
OBJECTIVES: The HIV-1 genetic diversity and the presence of transmitted drug resistance mutations (TDRMs) against integrase strand transfer inhibitors (INSTIs) were assessed sequencing samples of antiretroviral (ARV)-naive HIV-1-infected individuals from South Brazil. METHODS: Viral RNA from 42 ART-naive individuals was submitted to complete HIV-1 integrase gene amplification by RT-PCR and sequencing. RESULTS:...
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