Mutation Patterns of Integrase Gene Affect Antiretroviral Resistance in Various non-B Subtypes of Human Immunodeficiency Virus Type-1 and Their Implications for Patients’ Therapy

Abstract excerpt

Although primary integrase strand transfer inhibitor resistance mutations are currently uncommon, the increasing use of integrase strand transfer inhibitor as a key component of the first, second and third-line antiretroviral regimens suggests that the prevalence of integrase drug resistance mutations will likely increase. The rise of several polymorphic mutations and natural polymorphisms also affects the level...

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