Article
Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia.
Disease models & mechanisms - 1 Jan 2000
Tong Dan, Colley Deanne, Thoo Renee, Li Tony Y, Plante Isabelle, Laird Dale W, Bai Donglin, Kidder Gerald M
Abstract excerpt
The essential role of connexin43 (Cx43) during oogenesis has been demonstrated by the severe germ cell deficiency and arrested folliculogenesis observed in Cx43 knockout mice. Recently, another mutant mouse strain became available (Gja1(Jrt)/+) that carries the dominant loss-of-function Cx43 mutation, Cx43(G60S). Gja1(Jrt)/+ mice display features of the human disease oculodentodigital dysplasia (ODDD), which is...
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