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Article

Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a

12 Dec 2006

Abstract excerpt

In recent years, mammalian oocytes have been proposed to have important roles in the orchestration of ovarian follicular development and fertility. To determine whether intra-oocyte Foxo3a, a component of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, influences follicular development and female fertility, a transgenic mouse model was generated with constitutively active Foxo3a expressed in oocytes....

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PMID: 17164425
DOI: 10.1242/dev.02667

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