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Article

The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation.

Experimental dermatology - 1 Aug 2012

Churko Jared M, Kelly John J, Macdonald Andrew, Lee Jack, Sampson Jacinda, Bai Donglin, Laird Dale W

Abstract excerpt

Transient knock-down of the gap junction protein Cx43 by antisense and siRNA, or gap junction block with mimetic peptides, have been shown to enhance epidermal wound healing. However, patients with oculodentodigital dysplasia (ODDD) express mutant Cx43 that leads to a chronic reduction in gap junctional intercellular communication. To determine whether mutant Cx43 in keratinocytes would impact upon the wound...

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Identifiers

PMID: 22775996
DOI: 10.1111/j.1600-0625.2012.01532.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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