Article
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.
American journal of human genetics - 1 Mar 2009
Xiong Dong-Hai, Liu Xiao-Gang, Guo Yan-Fang, Tan Li-Jun, Wang Liang, Sha Bao-Yong, Tang Zi-Hui, Pan Feng, Yang Tie-Lin, Chen Xiang-Ding, Lei Shu-Feng, Yerges Laura M, Zhu Xue-Zen, Wheeler Victor W, Patrick Alan L, Bunker ClareAnn H, Guo Yan, Yan Han, Pei Yu-Fang, Zhang Yin-Pin, Levy Shawn, Papasian Christopher J, Xiao Peng, Lundberg Y Wang, Recker Robert R, Liu Yao-Zhong, Liu Yong-Jun, Zmuda Joseph M, Deng Hong-Wen
Abstract excerpt
To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.