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Article

Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair.

Cell cycle (Georgetown, Tex.) - 1 Jan 2005

Shah O Jameel, Hunter Tony

Abstract excerpt

The TSC1-TSC2 tumor suppressor complex serves as an interface between insulin and nutrient signaling pathways and the cell growth machinery. Recent work has indicated that the TSC1-TSC2 complex plays a role in the pathobiology of a number of tumor predisposition syndromes, including tuberous sclerosis (TSC1/2), Peutz-Jeghers syndrome (LKB1), and Cowden's syndrome (PTEN), in which the TSC/Rheb/mTOR axis is...

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Share to Hamartoma Syndrome, Multiple
Share to Insulin Receptor Substrate Proteins
Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peutz-Jeghers Syndrome

Share to Receptors, Thyroid Hormone

Share to Tuberous Sclerosis

Share to Tuberous Sclerosis Complex 1 Protein

Share to Tuberous Sclerosis Complex 2 Protein

Source

Identifiers

PMID: 15611656
DOI: 10.4161/cc.4.1.1343

Genes

TSC1
TSC2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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