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Article

Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages.

Scientific reports - 25 Jul 2023

Aridgides Daniel S, Mellinger Diane L, Gwilt Lorraine L, Hampton Thomas H, Mould Dallas L, Hogan Deborah A, Ashare Alix

Abstract excerpt

Macrophage dysfunction has been well-described in Cystic Fibrosis (CF) and may contribute to bacterial persistence in the lung. Whether CF macrophage dysfunction is related directly to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in macrophages or an indirect consequence of chronic inflammation and mucostasis is a subject of ongoing debate. CFTR modulators that restore CFTR function in epithelial...

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Identifiers

PMID: 37491532
DOI: 10.1038/s41598-023-38300-9
PMCID: PMC10368712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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