Article
Importance of purine and pyrimidine content of local nucleotide sequences (six bases long) for evolution of the human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991
Doi H
Abstract excerpt
Human immunodeficiency virus type 1 evolves rapidly, and random base change is thought to act as a major factor in this evolution. However, segments of the viral genome differ in their variability: there is the highly variable env gene, particularly hypervariable regions located within env, and, in contrast, the conservative gag and pol genes. Computer analysis of the nucleotide sequences of human...
Topics
- Acquired Immunodeficiency Syndrome
- Base Composition
- Base Sequence
- Biological Evolution
- Codon
- Databases, Factual
- Genetic Variation
- HIV-1
- Humans
- Purines
- Pyrimidines