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Article

Search for the mechanism of genetic variation in the pro gene of human immunodeficiency virus.

Journal of virology - 1 Oct 1999

Rouzine I M, Coffin J M

Abstract excerpt

To study the mechanism of evolution of the human immunodeficiency virus (HIV) protease gene (pro), we analyzed a database of 213 pro sequences isolated from 11 HIV type 1-infected patients who had not been treated with protease inhibitors. Variation in pro is restricted to rare variable bases which are highly diverse and differ in location among individuals; an average variable base appears in about 16% of...

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Identifiers

PMID: 10482567
DOI: 10.1128/JVI.73.10.8167-8178.1999
PMCID: PMC112834

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Source receipt: pubmed, retrieved 7 Sept 2026.

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