Article
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
The Journal of clinical endocrinology and metabolism - 1 Nov 2004
Maioli Mario, Alejandro Emilyn, Tonolo Giancarlo, Gilliam Lisa K, Bekris Lynn, Hampe Christiane S, Obinu Domenica A, Manconi Alberto, Puddu Loreta, Lynch Kristian, Lernmark Ake
Abstract excerpt
The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific GAD65Abs, or...
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