Article
Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
PloS one - 1 Jan 2009
Graubert Timothy A, Payton Michelle A, Shao Jin, Walgren Richard A, Monahan Ryan S, Frater John L, Walshauser Mark A, Martin Mike G, Kasai Yumi, Walter Matthew J
Abstract excerpt
Deletions spanning chromosome 5q31.2 are among the most common recurring cytogenetic abnormalities detectable in myelodysplastic syndromes (MDS). Prior genomic studies have suggested that haploinsufficiency of multiple 5q31.2 genes may contribute to MDS pathogenesis. However, this hypothesis has never been formally tested. Therefore, we designed this study to systematically and comprehensively evaluate all 28...
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