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Article

TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes.

Oncotarget - 27 Oct 2015

McGraw Kathy L, Cluzeau Thomas, Sallman David A, Basiorka Ashley A, Irvine Brittany A, Zhang Ling, Epling-Burnette P K, Rollison Dana E, Mallo Mar, Sokol Lubomir, Solé Francesc, Maciejewski Jaroslaw, List Alan F

Abstract excerpt

P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26416416
DOI: 10.18632/oncotarget.5255
PMCID: PMC4741464

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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