Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells

11 Jan 2013

Abstract excerpt

Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CM) is accompanied by changes in ion channel expression, with relevant electrophysiological consequences. In rodent CM, the properties of hyperpolarization-activated cyclic nucleotide-gated channel (HCN)4, a major f-channel isoform, depends on the association with caveolin-3 (Cav3). To date, no information exists on changes in Cav3 expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23311301
DOI: 10.1089/scd.2012.0247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem CellsPMID 23311301Read ↗

Non-Cardiomyocytes Influence the Electrophysiological Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes During DifferentiationSemantic proximity Read ↗

Electrical stimulation promotes maturation of cardiomyocytes derived from human embryonic stem cells.Semantic proximity Read ↗

Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological ApproachSemantic proximity Read ↗

Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth.Semantic proximity Read ↗

Ion channel expression and electrophysiology of singular human (primary and induced pluripotent stem cell derived) cardiomyocytesSemantic proximity Read ↗

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived CardiomyocytesSemantic proximity Read ↗

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.Semantic proximity Read ↗

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.Semantic proximity Read ↗

Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric MyocardiumSemantic proximity Read ↗

Maturation of human cardiac organoids enables complex disease modelling and drug discoverySemantic proximity Read ↗

Long-QT syndrome-associated caveolin-3 mutations differentially regulate the hyperpolarization-activated cyclic nucleotide gated channel 4.Semantic proximity Read ↗

Caveolin-3: a molecular insight into diseases of the heartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.