Article
Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger.
Malaria journal - 23 Feb 2009
Ibrahim Maman Laminou, Steenkeste Nicolas, Khim Nimol, Adam Hadiza Hassane, Konaté Lassana, Coppée Jean-Yves, Ariey Fredéric, Duchemin Jean-Bernard
Abstract excerpt
BACKGROUND: Over the last years, significant progress has been made in the comprehension of the molecular mechanism of malaria resistance to drugs. Together with in vivo tests, the molecular monitoring is now part of the survey strategy of the Plasmodium sensitivity. Currently, DNA-microarray analysis allows the simultaneous study of many single nucleotide polymorphisms (SNP) of Plasmodium isolates. In December...
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