Article
Ultraspecific probes for high throughput HLA typing.
BMC genomics - 20 Feb 2009
Feng Chen, Putonti Catherine, Zhang Meizhuo, Eggers Rick, Mitra Rahul, Hogan Mike, Jayaraman Krishna, Fofanov Yuriy
Abstract excerpt
BACKGROUND: The variations within an individual's HLA (Human Leukocyte Antigen) genes have been linked to many immunological events, e.g. susceptibility to disease, response to vaccines, and the success of blood, tissue, and organ transplants. Although the microarray format has the potential to achieve high-resolution typing, this has yet to be attained due to inefficiencies of current probe design strategies....
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