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High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays.

Genetic analysis : biomolecular engineering - 1 Feb 1999

Sapolsky R J, Hsie L, Berno A, Ghandour G, Mittmann M, Fan J B

Abstract excerpt

A highly reliable and efficient technology has been developed for high-throughput DNA polymorphism screening and large-scale genotyping. Photolithographic synthesis has been used to generate miniaturized, high-density oligonucleotide arrays. Dedicated instrumentation and software have been developed for array hybridization, fluorescent detection, and data acquisition and analysis. Specific oligonucleotide probe...

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PMID: 10084113
DOI: 10.1016/s1050-3862(98)00026-6

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