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Article

ATP acts as a regulatory effector in modulating structural transitions of cytochrome c: implications for apoptotic activity.

Biochemistry - 21 Apr 2009

Patriarca Antonella, Eliseo Tommaso, Sinibaldi Federica, Piro Maria Cristina, Melis Riccardo, Paci Maurizio, Cicero Daniel O, Polticelli Fabio, Santucci Roberto, Fiorucci Laura

Abstract excerpt

The binding of lipids (free fatty acids as well as acidic phospholipids) to cytochrome c (cyt c) induces conformational changes and partial unfolding of the protein, strongly influencing cyt c oxidase/peroxidase activity. ATP is unique among the nucleotides in being able to turn non-native states of cyt c back to the native conformation. The peroxidase activity acquired by lipid-bound cyt c turns out to be very...

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PMID: 19231839
DOI: 10.1021/bi801837e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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