Article
The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.
Biochimica et biophysica acta - 1 Dec 2014
van der Mark Vincent A, de Waart D Rudi, Ho-Mok Kam S, Tabbers Merit M, Voogt Heleen W, Oude Elferink Ronald P J, Knisely A S, Paulusma Coen C
Abstract excerpt
Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1 (BRIC1). Apart from cholestasis, many patients also suffer from diarrhea of yet unknown etiology. Here we have studied the hypothesis that intestinal ATP8B1 deficiency results in...
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