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Article

The assembly motif of a bacterial small multidrug resistance protein.

The Journal of biological chemistry - 10 Apr 2009

Poulsen Bradley E, Rath Arianna, Deber Charles M

Abstract excerpt

Multidrug transporters such as the small multidrug resistance (SMR) family of bacterial integral membrane proteins are capable of conferring clinically significant resistance to a variety of common therapeutics. As antiporter proteins of approximately 100 amino acids, SMRs must self-assemble into homo-oligomeric structures for efflux of drug molecules. Oligomerization centered at transmembrane helix four (TM4)...

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Identifiers

PMID: 19224913
DOI: 10.1074/jbc.M900182200
PMCID: PMC2665109

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