Article
CD8 T-cell responses against cyclin B1 in breast cancer patients with tumors overexpressing p53.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2009
Sørensen Rikke Baek, Andersen Rikke Sick, Svane Inge Marie, Engell-Noerregaard Lotte, Hadrup Sine R, Balslev Eva, Andersen Mads Hald, thor Straten Per
Abstract excerpt
PURPOSE: This study aimed to examine CD8 T-cell reactivity in breast cancer patients against cyclin B1-derived peptides restricted by the human leukocyte antigen (HLA)-A2 molecule. EXPERIMENTAL DESIGN: Peripheral blood mononuclear cells from 36 breast cancer patients were analyzed by enzyme-linked immunosorbent spot (ELISPOT) for the presence of T cells recognizing the cyclin B1-derived peptides CB9 (AKYLMELTM)...
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