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Article

Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Mar 2009

Najjar Amer M, Nishii Ryuichi, Maxwell David S, Volgin Andrei, Mukhopadhyay Uday, Bornmann William G, Tong William, Alauddin Mian, Gelovani Juri G

Abstract excerpt

UNLABELLED: Imaging 2 different molecular-genetic events in a single subject by PET is essential in a variety of in vivo applications. Using herpes simplex virus-1 thymidine kinase (HSV1-tk) mutants with narrower substrate specificities in combination with wild-type HSV1-tk (wtHSV1-tk) would enable differential imaging with corresponding radiotracers, namely...

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Identifiers

PMID: 19223410
DOI: 10.2967/jnumed.108.058735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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