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Article

Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging.

Molecular imaging and biology - 1 Feb 2017

Lee Jason T, Zhang Hanwen, Moroz Maxim A, Likar Yury, Shenker Larissa, Sumzin Nikita, Lobo Jose, Zurita Juan, Collins Jeffrey, van Dam R Michael, Ponomarev Vladimir

Abstract excerpt

PURPOSE: Radionuclide-based reporter gene imaging has the sensitivity to monitor gene- and cell-based therapies in human subjects. Potential immunogenicity of current viral transgenes warrants development of human-based reporter systems. We compared human nucleoside kinase reporters to a panel of nucleoside analogs of FEAU, FMAU, and FIAU, including the first in vivo assessment of L-[18F]FEAU. PROCEDURES: Human...

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Identifiers

PMID: 27393689
DOI: 10.1007/s11307-016-0981-6
PMCID: PMC5345744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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