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Article

Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice.

British journal of pharmacology - 1 May 2009

Medhurst A D, Roberts J C, Lee J, Chen C P L-H, Brown S H, Roman S, Lai M K P

Abstract excerpt

BACKGROUND AND PURPOSE: Histamine H3 receptor antagonists are currently being evaluated for their potential use in a number of central nervous system disorders including Alzheimer's Disease (AD). To date, little is known about the state of H3 receptors in AD. EXPERIMENTAL APPROACH: In the present study we used the radiolabelled H3 receptor antagonist [3H]GSK189254 to investigate H3 receptor binding in the amyloid...

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Identifiers

PMID: 19222483
DOI: 10.1111/j.1476-5381.2008.00075.x
PMCID: PMC2697792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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