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Article

A composite-likelihood approach for detecting directional selection from DNA sequence data.

Genetics - 1 Jul 2005

Zhu Lan, Bustamante Carlos D

Abstract excerpt

We present a novel composite-likelihood-ratio test (CLRT) for detecting genes and genomic regions that are subject to recurrent natural selection (either positive or negative). The method uses the likelihood functions of Hartl et al. (1994) for inference in a Wright-Fisher genic selection model and corrects for nonindependence among sites by application of coalescent simulations with recombination. Here, we (1)...

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Identifiers

PMID: 15879513
DOI: 10.1534/genetics.104.035097
PMCID: PMC1451173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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