Article
Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).
Cancer immunology, immunotherapy : CII - 1 Oct 2009
Elkord Eyad, Dangoor Adam, Burt Deborah J, Southgate Thomas D, Daayana Sai, Harrop Richard, Drijfhout Jan W, Sherlock David, Hawkins Robert E, Stern Peter L
Abstract excerpt
We have recently reported the results of a phase II trial in which two TroVax [modified vaccinia ankara (MVA) encoding the tumour antigen 5T4] vaccinations were given to patients both pre- and post-surgical resection of liver metastases secondary to colorectal cancer (CRC). 5T4-specific cellular responses were assessed at the entry and 2 weeks after each vaccination by proliferation of fresh lymphocytes and ELISA...
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