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Article

Absence of annulus in human asthenozoospermia: Case Report†

15 Feb 2009

Abstract excerpt

The annulus is a septin-based ring structure located at the junction of the midpiece (MP) and the principal piece (PP) of spermatozoa flagellum. In the mouse, deletion of Septin 4, a structural component of the sperm annulus, prevents annulus formation and leads to MP-PP disjunction, flagellar bending, asthenozoospermia and male sterility. Testis anion transporter 1 (Tat1) is a germ cell-specific member of the...

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PMID: 19221096
DOI: 10.1093/humrep/dep020

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