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Article

Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice.

The FEBS journal - 1 Feb 2009

Lord Anna, Englund Hillevi, Söderberg Linda, Tucker Stina, Clausen Fredrik, Hillered Lars, Gordon Marcia, Morgan Dave, Lannfelt Lars, Pettersson Frida E, Nilsson Lars N G

Abstract excerpt

Oligomeric assemblies of amyloid-beta (Abeta) are suggested to be central in the pathogenesis of Alzheimer's disease because levels of soluble Abeta correlate much better with the extent of cognitive dysfunctions than do senile plaque counts. Moreover, such Abeta species have been shown to be neurotoxic, to interfere with learned behavior and to inhibit the maintenance of hippocampal long-term potentiation. The...

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Identifiers

PMID: 19215301
DOI: 10.1111/j.1742-4658.2008.06836.x
PMCID: PMC2752010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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