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Article

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.

International journal of oncology - 1 Mar 2009

Watanabe Masami, Kashiwakura Yuji, Huang Peng, Ochiai Kazuhiko, Futami Junichiro, Li Shun-Ai, Takaoka Munenori, Nasu Yasutomo, Sakaguchi Masakiyo, Huh Nam-Ho, Kumon Hiromi

Abstract excerpt

The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated that recombinant REIC/Dkk-3 protein induced the differentiation of human CD14+ monocytes into a novel cell type (REIC/Dkk-3Mo). REIC/Dkk-3Mo resembles immature...

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PMID: 19212670
DOI: 10.3892/ijo_00000191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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