Induction of suppressive phenotype in monocyte-derived dendritic cells by leukemic cell products and IL-1β.

doi:10.1016/j.humimm.2014.04.013

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Article

Induction of suppressive phenotype in monocyte-derived dendritic cells by leukemic cell products and IL-1β.

Human immunology - 1 Jul 2014

Motta Juliana Maria, Sperandio Aline, Castelo-Branco Morgana Teixeira Lima, Rumjanek Vivian Mary

Abstract excerpt

Professional antigen-presenting cells, dendritic cells (DCs) play an important role in controlling tumors. It is known that solid tumor cell products inhibit DC differentiation. Recently a similar effect produced by leukemic cell products has been demonstrated. In this case, leukemic cell products induced the secretion of IL-1β by monocytes undergoing differentiation. The aim of the present work was to...

Topics

Antigens, CD
Antigens, Differentiation, Myelomonocytic
B7-1 Antigen
Cell Communication
Cell Differentiation
Coculture Techniques
Culture Media, Conditioned
Dendritic Cells
GPI-Linked Proteins
Gene Expression
Genotype
Granulocyte-Macrophage Colony-Stimulating Factor

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DR Antigens

Humans

Immunoglobulins

Interleukin-10

Interleukin-12

Interleukin-1beta

Source

Open in PubMed

Identifiers

PMID: 24768898
DOI: 10.1016/j.humimm.2014.04.013

Provenance

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