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Article

Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine.

American journal of physiology. Renal physiology - 1 Apr 2009

Schmitt Bernhard M, Gorbunov Dmitry, Schlachtbauer Peter, Egenberger Brigitte, Gorboulev Valentin, Wischmeyer Erhard, Müller Thomas, Koepsell Hermann

Abstract excerpt

Uptake of substrate and electric charge was measured simultaneously in voltage-clamped Xenopus laevis oocytes expressing rat organic cation transporter 2 (rOCT2). At 0 mV, saturating substrate concentrations induced uptake of more positive elementary charges than monovalent organic cations, with charge-to-substrate ratios of 1.5 for guanidinium(+), 3.5 for tetraethylammonium(+), and 4.0 for...

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Source

Identifiers

PMID: 19211691
DOI: 10.1152/ajprenal.90323.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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