Article
Interleukin 10 gene promoter polymorphisms in women with pregnancy loss: preferential association with embryonic wastage.
Biology of reproduction - 1 Jun 2009
Cochery-Nouvellon Eva, Nguyen Philippe, Attaoua Redha, Cornillet-Lefebvre Pascale, Mercier Eric, Vitry Fabien, Gris Jean-Christophe
Abstract excerpt
Interleukin 10 (IL10) is associated with maternal immunotolerance. IL10 also down-regulates decidual cell tissue factor expression, the main molecule triggering coagulation activation: this antithrombotic effect may protect the umbilicoplacental vasculature from the 10th wk of gestation onward. IL10 down-regulation may thus dispose to early pregnancy loss (PL) due to maternal immunotolerance defect or late...
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