Article
Interleukin 10-2849AA genotype protects against pre-eclampsia.
Genes and immunity - 1 Jun 2004
de Groot C J M, Jansen M W J C, Bertina R M, Schonkeren J J M, Helmerhorst F M, Huizinga T W J
Abstract excerpt
Recently, it has been described that human fertility is associated with the interleukin 10 (IL10) -2849 AA genotype. Pre-eclampsia is the most common pregnancy-specific complication. In the pathogenesis of pre-eclampsia, IL10 may affect maternal intravascular inflammation as well as endothelial dysfunction. Therefore, we tested the hypothesis that pre-eclampsia is associated with genetic variation in the IL10...
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