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Article

Epigenetic role of LINE-1 methylation and key genes in pregnancy maintenance.

Scientific reports - 8 Feb 2024

Tisato Veronica, Silva Juliana A, Scarpellini Fabio, Capucci Roberta, Marci Roberto, Gallo Ines, Salvatori Francesca, D'Aversa Elisabetta, Secchiero Paola, Serino Maria L, Zauli Giorgio, Singh Ajay V, Gemmati Donato

Abstract excerpt

Spontaneous abortion is a pregnancy complication characterized by complex and multifactorial etiology. About 5% of childbearing women are globally affected by early pregnancy loss (EPL) and most of them experience recurrence (RPL). Epigenetic mechanisms and controlled inflammation are crucial for pregnancy maintenance and genetic predispositions may increase the risk affecting the maternal-fetal crosstalk....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38332006
DOI: 10.1038/s41598-024-53737-2
PMCID: PMC10853191

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